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Hyperbaric Oxygenation improves altered T2 signal intensities in brain and spinal cord and cerebrospinal disturbances Kono Y, Nakamori T, Imafuku I, Washizaki K, Kunimoto M. Department of Neurology, Yokohama Rosai Hospital. A 26-year-old woman was admitted to our hospital for the treatment of hyperbaric oxygen therapy to acute carbon monoxide intoxication. The consciousness disturbance improved and she was discharged after 23 times of the hyperbaric oxygen therapy. However, she was readmitted because of dementia and urinary incontinence after 22 days. Diffusion-weighted images showed bright high signal intensities in the periventicular white matter and corpus callosum. The condition was considered to be an interval form of carbon monoxide intoxication. She was treated by 38
times of the hyperbaric oxygen therapy with cytochrome C and
fully recovered. MRI images and cerebrospinal fluid
abnormality (high protein content and IgG index) became
normalized somewhat later than the improvement of the
symptoms. By an investigation utilizing diffusion-weighted
images, we thought that not only the demyelination which
mentioned formerly, but the vasogenic edema was involving in
the mechanism of these high signal intensities in the
periventicular white matter of the interval form. And in the
range which we searched, this is the first report which
mentioned the abnormal findings of cerebrospinal fluid in an
interval form of carbon monoxide intoxication. So we believe
this case is very important for telling us suspected the
mechanism and some indications about the treatment of an
interval form.
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