Presented at the 2nd International Symposium on Hyperbaric Oxygenation for Cerebral Palsy and the Brain-Injured Child Boca Raton, Florida July 25-28, 2001

Campbell AW, MD**, Anyanwu E, MS, PhD**, High W, MD, PhD**, Vojdani A. MT, PhD* **

Center for Immune, Environmental & Toxic Disorders 25010 Oakhurst, Suite 200, Spring, Texas 77386;
Tel: 281-364-1013 Fax: 281-364-0492.

*Immunosciences Lab, Incorporated, Beverly Hills, California. Center for Immune, Environmental & Toxic Disorders 25010 Oakhurst, Suite 200, Spring, Texas 77386;
Tel: 281-364-1013 Fax: 281-364-0492.

Abstract Purpose: The causal involvement of adverse hepatitis B vaccines in cerebral palsy and epilepsy, remains controversial. In this study, we report a case report of a 21 month-old white female patient who presented with recurrent seizures and manifested all characteristic features of cerebral palsy as a result of hepatitis B vaccines.

Methods: neuroimmunologic techniques, family history, and previous medical records were used to evaluate, correlate and ascertain whether cerebral palsy and epilepsy were a consequence of hepatitis B vaccines adverse effects.

Results: Abnormal EEG showed bilateral cerebral hemispheric disturbances with abnormal rhythmic and irregular delta wave activity was present suggesting an underlying cortical rhythms, less evident in the area of involvement. Furthermore, there was 4 Hz, paroxysmal bilaterally synchronous generalized focal theta activity suggesting damage to a non-specific thalmo-cortical region. Also, multiple theta wave discharges were seen independently arising from different regions of the hemispheres suggesting several potentially epileptogenic foci. The immunologic evaluation showed multiple antibody abnormalities including T helper/suppressor ratio and immune complexe! s. Certain abnormal antibodies found in epilepsy (IgG, IgA) were present in all the patients. There was an elevation of Mg2+ ions receptor function probably, as a result of autoimmune dysfunction.

Conclusions: Since there were no known family history of individuals with developmental problems, mental retardation, or seizure disorders, it then meant that her health condition was related to after birth events. Hence, those abnormalities that are associated with neurological dysfunctions, and characteristics that are found in cerebral palsy and epilepsy, are most likely associated with hepatitis B vaccines adverse effects.