Oxygen therapy improves energy metabolism in focal cerebral ischemia
Oxygen therapy (OT) with hyperbaric oxygen (HBO) or normobaric hyperoxia (NBO) improves the oxygenation of penumbral tissue in experimental ischemic stroke
Hyperbaric oxygen treatment of musculoskeletal disorders on the sports medicine. State of the art
Oxygen therapy improves energy metabolism in focal cerebral ischemia
We conclude that HBO(2) T stimulates vasculogenic stem cell mobilization from bone marrow of diabetics and more cells are recruited to skin wounds.
Effect of Oxygenation on stem-cell therapy for myocardial infarction
Stem-cell transplantation (MSC) to treat acute myocardial infarction (MI) is gaining importance as a minimally invasive and potent therapy to replace akinetic scar tissue by viable myocardium. The myocardial pO(2) in theMSC+HBOgroup (16.2±2.2 mmHg) was significantly higher when compared to untreated MI (3.8±1.9 mmHg) or MSC (9.8±2.3 mmHg) groups. In addition, there was a significant improvement in cardiac function, increased vessel density, and VEGF expression in MSC+HBO group compared to MSC group (p < 0.05). In conclusion, the results suggested a beneficial effect of HBO administration on stem-cell therapy for MI.
Hyperbaric Oxygen therapy for transient bone marrow oedema syndrome of the hip
Magnetic Resonance Imaging at 3 months showed resolution of bone marrow oedema in 55.0% of the patients treated with hyperbaric Oxygen compared with 28% in the control group. Hyperbaric Oxygen therapy appears to be effective in treating transient bone marrow oedema syndrome, resulting in an accelerated recovery of hip function compared to pharmacological therapy alone.
Creation of a prevascularized site for cell transplantation in rats.
As ischemia-damaged cells are likely to undergo cell death or loose functionality due to hypoxia, therefore leading to graft dysfunction, the combination foam+VAC and HBO might be a promising method to create a prevascularized site to achieve better results in xenogeneic cell transplantation.
Beneficial effects of hyperbaric Oxygen on human degenerated intervertebral disk cells via suppression of IL-1beta and p38 MAPK signal. Orthop Res. 2010 Jul 26. [Epub ahead of print]
Niu CC, Yuan LJ, Chen LH, Lin SS, Tsai TT, Liao JC, Lai PL, Chen WJ. Department of Orthopaedic Surgery and Hyperbaric Oxygen Therapy Center, Chang Gung Memorial Hospital, No 5, Fu-Hsing Street 333, Kweishan, Taoyuan, Taiwan.
Abstract: Nucleus pulposus cells (NPCs) from degenerating disks produce catabolic and inflammatory factors, including interleukin (IL)-1, nitric oxide (NO), prostaglandin E2 (PGE-2), and matrix metalloproteinaes (MMPs). An imbalance between MMPs and tissue inhibitors of matrix metalloproteinases (TIMPs) has been proposed to exist in the degenerating disk. This study evaluates the effects of hyperbaric Oxygen (HBO) on the human degenerated NPCs. NPCs were maintained in alginate bead culture. All hyperoxic cells were exposed to 100% O(2) at 2.5 atmospheres absolute (ATA) in a hyperbaric chamber. p38 MAPK phosphorylation of the NPCs was detected using the phosphor-kinase array kit. RNA was isolated for real-time quantitative polymerase chain reaction (Q-PCR) analysis of aggrecan and type II collagen gene expression. The amounts of IL-1beta, NO, PGE-2, MMP-3, and TIMP-1 in the conditioned media were quantified by enzyme-linked immunosorbent assay (ELISA). Our data showed that HBO treatment decreased expression of IL-1beta, increased the gene expression of aggrecan and type II collagen, suppressed the phosphorylation of p38 MAPK, decreased NO, PGE-2, and MMP-3, and increased TIMP-1 expression in NPCs as compared with the atmospheric treatment. These results support the hypothesis that IL-1beta and the p38 MAPK signal may be responsible for many of the inflammatory and catabolic changes seen in the human disk degeneration, and support our proposal that HBO treatment-induced increase of the anabolic factor (TIMP-1)/catabolic factor (MMP-3) ratio may provide a therapeutic approach to slow the course of intervertebral disk degeneration. (c) 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.
Hyperbaric Oxygen Therapy in Femoral Head Necrosis
Camporesi EM, Vezzani G, Bosco G, Mangar D, Bernasek TL. University of South Florida, Tampa, Florida. J Arthroplasty. 2010 Jul 14. [Epub ahead of print]
Abstract: We evaluated hyperbaric Oxygen (HBO) therapy on a cohort of patients with femoral head necrosis (FHN). This double-blind, randomized, controlled, prospective study included 20 patients with unilateral FHN. All were Ficat stage II, treated with either compressed Oxygen (HBO) or compressed air (HBA). Each patient received 30 treatments of HBO or HBA for 6 weeks. Range of motion, stabilometry, and pain were assessed at the beginning of the study and after 10, 20, and 30 treatments by a blinded physician. After the initial 6-week treatment, the blind was broken; and all HBA patients were offered HBO treatment. At this point, the study becomes observational. Pretreatment, 12-month. and 7 year-follow-up magnetic resonance images were obtained. Statistical comparisons were obtained with nonparametric Mann-Whitney U test. Significant pain improvement for HBO was demonstrated after 20 treatments. Range of motion improved significantly during HBO for all parameters between 20 and 30 treatments. All patients remain substantially pain-free 7 years later: none required hip arthroplasty. Substantial radiographic healing of the osteonecrosis was observed in 7 of 9 hips. Hyperbaric Oxygen therapy appears to be a viable treatment modality in patients with Ficat II FHN. Copyright © 2010. Published by Elsevier Inc.
Spinal cord injuries include original injury and secondary injury. The aim of therapy is to prevent and reduce the secondary injury. The traditional therapy can alleviate the secondary injury of spinal cord through surgery that can both relieve the pressure of spinal cord and maintain the spinal stability with the internal fixation, medicine and hyperbaric Oxygen therapy were applied together. But, the effect of neuroprotection and neurotization of traditional therapy is worse and the most of all is the environment in the spinal cord injury that make against the repairing. At present, the treatment of spinal cord injury with cell transplantation and gene therapy have made achievements in the animal experiment and have been simply tested in clinical. Cell transplantation and gene therapy have a great clinical utilization.
It was found that HBO2 therapy significantly attenuated the SCI-induced hind limb dysfunction, spinal cord infarction and apoptosis, and overproduction of spinal cord interleukin-1beta and tumor necrosis factor-alpha. In contrast, the numbers of both GDNF-positive and VEGF-positive cells and production of spinal cord interleukin-10 during SCI were all significantly increased by HBO2. Data suggested that HBO2 may have attenuated experimental SCI by stimulating production of GDNF, VEGF and interleukin-10.
Hyperbaric Oxygen therapy and age-related macular degeneration.
Age-related macular degeneration (AMD) is a significant cause of visual loss in the United States and Western Europe. As the population ages, the prevalence rate of advanced AMD is expected to double by 2030. A one-hour session of hyperbaric Oxygen therapy (HBO2) was used to treated a group of 14 patients with advanced AMD. Eight patients were treated at 1.75 ATA, and six patients were treated at 1.5 ATA for one hour. Significant improvements in visual acuity and/or visual field, with improvements in the activities of daily living were observed.
Hyperbaric Oxygen-stimulated proliferation and growth of osteoblasts
Positive Influence of Hyperbaric Oxygenation on Recovery from Brain Trauma
Hyperbaric Oxygen Therapy Treatment of Chronic Mild-Moderate Blast-Induced Traumatic Brain Injury/Post Concussion Syndrome with Post Traumatic Stress Disorder: Pilot Trial
Case report: Treatment of mild traumatic brain injury with hyperbaric Oxygen
Hyperbaric Oxygen Therapy in Chronic Stable Brain Injury (HYBOBI)
Effect of hyperbaric Oxygen on mesenchymal stem cells for lumbar fusion
Treatment of Traumatic Brain Injury With Hyperbaric Oxygen Therapy
Hyperbaric Treatments for Children With Cerebral Palsy
Effects of Hyperbaric Oxygen Therapy on Children With Autism
Effects of Hyperbaric Oxygen Therapy in Autistic Children: A Pilot Study
Hyperbaric Oxygen Therapy in Chronic Stable Brain Injury
Hyperbaric Oxygenation role in White Matter Hyperintensities - Hyperbaric Oxygen Treatment In Patients With White Matter Hyperintensities On Magnetic Resonance Imaging and Neurologic Deficits
Efficacy of Hyperbaric Oxygen Therapy in Laryngectomy Patients
Hyperbaric Oxygen Therapy (HBOT) for Chronic Diabetic Lower Limb Ulcers
Hyperbaric Oxygen Therapy as Adjunctive Treatment of Chronic Diabetic Foot Ulcers (HODFU)
Hyperbaric Oxygen Therapy and SPECT Brain Imaging in Traumatic Brain Injury
Preconditioning With Hyperbaric Oxygen in Cardiovascular Surgery
The Protective Effects Of Treatment With Hyperbaric Oxygen Prior To Bypass Heart Surgery
Randomized Controlled Trial of Hyperbaric Oxygen in Patients Who Have Taken Bisphosphonates
Hyperbaric Oxygen Treatment of Mandibular Osteoradionecrosis. A Randomized Clinical Study
