'Integrative Medicine refers to the blending of conventional (medical) and natural/complementary medicines and/or therapies along with lifestyle interventions and a holistic approach with the aim of using the most appropriate, safe and evidence-based modality(ies) available'.
AIMA joint working party/RACGP : ‘Best Practice’ document
Drugs help as long as they are taken
Apart from surgery, conventional medicine is relying on
pharmaceutical drugs. Besides their undoubted benefits, they
have certain shortcomings which are often overlooked.
Drugs only help as long as they are taken,
after a prolonged treatment all drugs impair the body,
in the long run unwanted side effects dominate the treatment
and might be life threatening
Effective treatment with reliable long lasting results, even
with the chance of curing the underlying problem, only is
possible when the body heals itself. Ancient and most up to date
treatment procedures do address exactly this issue.
Integrated medicine describes a medical approach...
which stimulates, modifies, accelerates the expression of
cellular hormones. These methods work all in the same direction,
they even can induce stem cell and growth factor 'wandering'
(homing) to the place where nerves, bones cartilage, tendons or
muscles have to heal.
The Final Frontier - 'Anti
Aging - Repair and Functional Restoration' -
The final frontier in
health and well being is 'anti-aging' and the factors that
Telomere length (LTL)
is an emerging marker of biological age.
activity (aging) is commonly proposed as a promoter of biological
aging in general, and of leukocyte
in particular. In addition, senescent cells with critically
short telomeres produce
pro-inflammatory factors. However, in spite of the proposed
causal links between inflammatory activity and LTL, there is
little clinical evidence in support of their covariation and
levels of the systemic inflammatory markers interleukin-6
factor-α (TNF-α) and
C-reactive protein (CRP) had increased odds for short LTL.'
Targets Chronic Inflammation
The positive clinical effects
in the treatment of chronic inflammation is due to the effects
local and systemic
Tumor Necrosis Factor
The effects of Hyperbaric Oxygenation on
Cytokines indicates that HBO has important effects on the
biology of cytokines and other mediators of inflammation.
HBO improves Telomere function slowing degeneration.
Hyperbaric Oxygenation causes
down regulation of inflammatory cytokines and the
stabilization and repair. HBO suppresses stimulus-induced proinflammatory cytokine production
reducing the release of
Factor -alpha (TNF-a) and
- immune response
IL-1β, IL-2, IL-6, tumor
nitric oxide synthase,
cytochrome c, caspase 3,
and Bax are down-regulated by IL-10,
factors Bcl-2 and Bcl-xl
are up-regulated by
IL-10 also provides
trophic support to
the IL-10 receptor. Increased tissue
recovery, and neuroprotection are seen
with an immediate
administration of IL-10.
Mobilization and Vascular Endothelial
levels are significantly increased with HBO therapy
(100% O2 @ 1.8-2.0 ATA); whereas levels of
prostaglandin E2 and cyclo-oxygenase-2 mRNA
are markedly reduced. Therefore, the
anti-inflammatory and immunosuppressive
properties of Hyperbaric Oxygenation might account for its
efficacy in the treatment and management of
The extent of neurovascular deterioration can be significantly diminished with Hyperbaric Oxygenation (HBOT) which 'expands the therapeutic window'.
What is Hypoxia?
- increases (upregulates) stem cell proliferation and neurovascular growth factors; neuronal activation; interrupts the hypoxic cascade of degeneration.
plays key roles in maintaining chromosome stability and cell
Telomere shortening occur
concomitant with aging.
Chronic inflammatory activity is commonly proposed as a promoter
of biological aging in general, and of leukocyte
telomere shortening. High
levels of the systemic inflammatory markers interleukin-6
factor-α (TNF-α) and
C-reactive protein (CRP) had increased odds for short Telomeres
The final frontier in the treatment of sporting injuries to complex orthopaedic and degenerative neurovascular disorders including brain and spinal cord injury is focused on ‘repair and functional restoration’. Patients
with complex disorders and chronic illness require a tailored
Derived Autologous Stem Cells combined with the enhanced effects
of HBO stem cell mobilization is recommended with neuropeptide
to promote axonal sprouting, activation of idling and non-functional neurons whilst promoting neovascularization (new capillary formation) of damaged areas.
Autologous Stem Cells are often combined with Platelet Rich
Plasma (Growth Factors) to assist delivery and patient outcomes.
Platelet Rich Plasma
Blood contains plasma, red blood cells, white blood cells and platelets. Platelets contain clotting and growth factors. During the healing process, the platelets are activated and aggregate together. They then release the growth factors which stimulate the healing process.
Normal blood typically contains 6% platelets whereas PRP enriched platelet concentration can contain 4 times (400%) greater concentrations of enriched growth factors. Hyperbaric Oxygenation PLUS PRP targeted injections accelerate recovery.
Anti -TNF Treatment Modalities
Tumor necrosis factor-alpha (TNF-alpha) is a cytokine produced by monocyte and macrophage white blood cells which acts as the master regulator of the human inflammatory response. Excess TNF-alpha in the brain can disrupt synaptic communication. Excess TNF-alpha triggers a cycle whereby toxic amyloid-beta is produced. This results in greater levels of pro-inflammatory TNF-alpha.
Etanercept (Enbrel) is a fusion of two proteins naturally occurring in the human body that was developed to treat various inflammatory diseases by binding to TNF-alpha, effectively neutralizing its ability to act on cell membranes. Enbrel treatment has a rapid effect, reversing cognitive impairment, and validating the role excess TNF-alpha has in the Alzheimer's disease process. Enbrel's long half life (70 to 132 hours) enables a series of treatments to produce sequential progressive improvements in cognitive function that can be maintained long term.
Alzheimer's is an inflammatory disease of the brain. Reducing neuroinflammation results in improvements in memory, mood, and cognitive function. Etanercept is a powerful anti-inflammatory agent. The administration of perispinal Etanercept can result in rapid and dramatic improvements in cognitive function in persons with Alzheimer's disease and numerous other neurodegenerative disorders.
Cerebrolysin is a mixture of different neurotrophic factors e.g., brain-derived neurotrophic factor (BDNF), glial cell line derived neurotrophic factor (GDNF), nerve growth factor (NGF), ciliary neurotrophic factor (CNTF) and other peptide fragments.
Cerebrolysin is a compound with neurotrophic and neuroprotective activity that causes neuronal differentiation (sprouting of axons and dendrites) and maintains the functional integrity and recovery of the nerve cell.
Peptidergic Drugs for the
Treatment of Traumatic Brain Injury (2013)
a semiparasitic plant
that grows on several types of trees, including apple, oak, maple, elm, pine,
and birch. It has been used for centuries to treat medical conditions such as
epilepsy, hypertension, headaches, menopausal symptoms, infertility, arthritis
Mistletoe is one of the most
widely studied complementary
and alternative medicine therapies for
cancer. In certain European countries, extracts made
from European mistletoe are among the most prescribed therapies
for cancer patients.
- is a tetrasubstituted 30-amino acid peptide hormone, primarily functioning as a growth hormone releasing hormone (GHRH) analog.
- designed originally as an Anti Obesity Drug (AOD) moving old mature fat deposits in the viscera. AOD can stimulate osteogenesis (new bone formation) and improve the mechanical properties of bone in osteoporosis.
This encouraging efficacy data when combined with the very favourable safety profile of AOD9604 in toxicology studies and human clinical trials provides a strong rationale for use in settings where bone and soft tissues are compromised. Examples include non-union fractures, osteoporosis, arthritis and indications where bone growth and supporting ligaments structures need to be stimulated.
Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-β) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass.
Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
Clinical Research/2008 Myostatin inhibition by a follistatin-derived ameliorates Muscular Dystrophy
Low-dose naltrexone (LDN) is a safe, inexpensive, yet underused drug that is extremely beneficial for patients with any condition marked by immune system dysfunction.
Naltrexone has been used in 50 mg doses for decades to help patients recover from addiction to alcohol, heroin, and other opiate drugs. However, more than 20 years ago it was discovered that very small doses of this drug—3 to 4.5 mg—have profound effects on the immune system. LDN works by boosting levels of endorphins, peptides produced in the brain and adrenal glands, that are best known for relieving pain and enhancing sense of well-being—they're responsible for the "runner's high" brought on by strenuous exercise. But these natural peptides are also powerful modulators of the immune system. When LDN is taken at bedtime, it attaches to opioid receptors and temporarily blocks endorphins from attaching. This signals the body to increase production of endorphins, which helps orchestrate the activity of stem cells, macrophages, natural killer cells, T and B cells, and other immune cells. As a result, LDN enhances the body's ability to fight disease.
Neuroprotection | Neurotransmitter | Neurotrophin | Antioxidant | Osmolyte anti-inflammatory
TAU promotes neurological function - neurotransmitter/neuromodulator, neurotrophin, antioxidant, and osmolyte. TAU levels are increased following brain injury and glucocorticoid administration and demonstrates strong neuroprotection and regeneration following injury. TAU neuroprotector effect favored restoration of the motor function of posterior extremities in rats with the model spinal cord trauma. TAU normalized the energy metabolism, lipid peroxidation and antioxidant system in animals with spinal cord trauma. TAU administration could prevent the onset of diabetes mellitus and/or insulin resistance type 1 and 2 diabetes mellitus. TAU reverses neurological and neurovascular deficits in experimental type 2 diabetes. TAU improves Potassium and Calcium regulation in the brain and nervous system decreasing the effects of encephalopathy. TAU concentrations in cerebrospinal fluid in experimental acute liver failure are increased early in the progression of encephalopathy and prior to the onset of cerebral edema, a potentially fatal complication of acute liver failure. These findings suggest an osmoregulatory role for taurine in brain in acute liver failure. TAU modulates as an anti-anxiety agent in the central nervous system TAU supplementation prevents high-fat diet-induced obesity with increased resting energy expenditure. TAU deficiency is associated with obesity and may create a vicious circle promoting obesity. Dietary TAU supplementation interrupts this vicious circle and may prevent obesity. TAU is cardio-protective; reduces and prevents the incidence of cardiac arrhythmias and protects against free radicals damage. TAU restores energy and endurance of debilitated cardiac patients. TAU dampens activity of the sympathetic nervous system and dampens epinephrine release. TAU protects against crush injury to brain and spinal cord (ischemia-reperfusion injury). TAU influences bone metabolism and promotes production of osteoblasts essential for non-healing fractures. TAU has platelet-stabilizing and anti-hypertensive effects that reduce coronary risk and infarction. TAU improves exercise time to exhaustion and maximal workload and enhances the capacity of exercise due to its cellular protective properties. In cases of extreme pancreatitis - histopathologic findings improved significantly after TAU supplementation.
Elevated TAU levels in the hippocampus and caudate nucleus promotes recovery and membrane stabilization after neuronal hyperactivity and seizure activity – reduces incidence and severity of seizures.
Both TAU and zinc provide protection of neurons against hypoxic damage. TAU protects the integrity of the hepatic (liver) tissue and proves efficacious as an antioxidant in tamoxifen-induced hepatotoxicity.
MSM is effective in treating and range of disorders from arthritis to chronic inflammatory disorders.
Derivatives of MSM include methionine, glutamine, cysteine and cysteine which are powerful precursors to Gluthathione production in the body. MSM strong antioxidant properties. MSM is neuroprotective when combined with Rehab Plus (Oxy-Sports) and N-Acetylcysteine (Oxy-Sports). MSM reduces inflammation with painful arthritis. MSM promotes circulation for musculoskeletal development and healing. MSM reduces muscle spasms. MSM reduces and softens scar formation. MSM slow the progression of degenerative arthritis. MSM promotes soft tissue and cartilage repair. MSM promotes joint flexibility reduces stiffness. MSM reduces symptoms associated with irritable bowel. MSM relieves constipation and promotes diuretic balance. MSM increases energy and endurance. MSM provides relief of numerous allergy symptoms. MSM improves immune stimulation – anti parasitic, anti viral, anti bacterial. MSM assists liver function and detoxification. MSM promotes healthy skin, hair and nails
NAC is a precursor of glutathione (neurotransmitter), a potent antioxidant, and a free radical scavenger.
HBOT with NAC increases fibroblast proliferation promoting neuro-musculoskeletal function and repair. NAC causes vasodilatation; NAC may be of benefit in acute myocardial infarction and other chronic ischemic disorders. NAC is neuro-protective effect preventing trauma-induced oxidative brain tissue damage. NAC promotes and protects Blood Brain Barrier (BBB) function. NAC reduces chronic BBB inflammation and swelling causing hypoxia. NAC results in a reduction body weights, and a marked reduction in visceral fat tissues (adipogenesis). NAC may be useful as an anti-obesity drug or supplement. NAC enhances T cell function in HIV infected patients and other chronic immunosuppressive disorders. NAC high-dose oral has the potential to counter the intertwined redox and inflammatory imbalances associated with Cystic Fibrosis and other obstructive airways disorders and chronic respiratory infections. NAC is widely used as an antioxidant, but also protects pancreatic beta cells in type 1 diabetes.